Asian Journal of Research in Chemistry

Vijay Jadhav ¹, Chandrakant Raut ¹, Pandurang N. Dhabale ¹

Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN

Abstract

A new, simple, specific, sensitive, accurate, precise and economical procedure for determination of Fenofibrate in their tablet dosage form has been developed using Zero order and Second Order Derivative Method. In the proposed method, the signals of absorbance maxima were measured at 285.5 nm in methanol solvent. The method based on the native ultraviolet absorbance maxima. The drug obeyed Beer’s law in the concentration range from 03-30 μg/ml in method. The results of analysis have been validated statistically and by recovery studies. The method shows good repeatability and recovery with % RSD is less than 2. The precision and accuracy of method were confirmed by repeatability and by recovery studies.

Keywords

Absorbance Maxima, Fenofibrate, Derivative Spectroscopy.

Full Text

     

Pandurang N. Dhabale ¹, Vijay Jadhav ¹, Chandrakant Raut ¹

Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN

Abstract

A new, simple, specific, sensitive, accurate, precise and economical procedure for determination of atorvastatin calcium in tablet dosage form has been developed using Zero order and Second Order Derivative Method. In the proposed method, the signals of absorbance maxima were measured at 247.5 nm. The method based on the native ultraviolet absorbance maxima. The drug obeyed Beer’s law in the concentration range from 3 μg/ml to 30 μg/ml. The results of analysis have been validated statistically and by recovery studies. The method shows good repeatability and recovery with % RSD is less than 2. The precision and accuracy of method were confirmed by repeatability and by recovery studies. These methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines.

Keywords

Absorbance Maxima, Atorvastatin Calcium, Derivative Spectroscopy.

Full Text

     

Deepali Gharge ¹, Pallavi Salve ¹, Chandrakant Raut ¹, Chottaram Seervi ¹, Kundan Pawar ¹, Pandurang Dhabale ¹

Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S, IN

Abstract

Aceclofenac is a non steroidal anti-inflammatory drug with good analgesic and anti-rheumatic properties. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed a new, precise and simple UV spectrophotometric method for estimation of aceclofenac from tablet formulation. The drug obeyed the Beer’s law and showed good correlation. Absorption maxima of aceclofenac in methanol diluted with glass double distilled water was found to be at 273 nm. Beer’s law was obeyed in concentration range 2-20 mcg/ml. The results of analysis were validated by recovery studies. The recovery was more than 99%. The method was found to be simple, accurate, precise, economical and robust.

Keywords

Aceclofenac, UV-Spectrophotometry, Recovery, Accuracy.

Full Text

     

Deepali Gharge ¹, Pallavi Salve ¹, Chandrakant Raut ¹, Kundan Pawar ¹, Pandurang Dhabale ¹

Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN

Abstract

Microwave chemistry involves the use of microwave radiation to conduct chemical reactions, and essentially pertains to chemical analysis and chemical synthesis. The fundamental mechanism of microwave heating involves agitation of polar molecules or ions that oscillate under the effect of an oscillating electric or magnetic field. In the presence of an oscillating field, particles try to orient themselves or be in phase with the field. Only materials that absorb microwave radiation are relevant to microwave chemistry. These materials can be categorized according to the three main mechanisms of heating, namely:Dipolar polarization, Conduction mechanism, Interfacial polarization. Microwave chemistry apparatus are classified:Single-mode apparatus and Multi-mode apparatus.

Keywords

Microwave Chemistry, Microwave Synthesis, Mechanism, Advantages.

Full Text

     

Chhotaram Seervi ¹, Kundan Pawar ¹, P. N. Dhabale ¹, I. D. Gonjari ¹, Chandrakant Raut ¹, Deepali Gharge ¹

Affiliations
1 Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, IN

Abstract

Two simple, precise and economical UV methods have been developed for the estimation of Ambroxol Hydrochloride in bulk and pharmaceutical formulations. Ambroxol Hydrochloride has the absorbance maxima at 246.5 nm (Method A), and in the first order derivative spectra showed sharp peak at 240 nm (Method B). Linearity for detector response was observed in the concentration range of 10-50 μg/ml for all two methods. The proposed methods were successfully applied for the estimation of Ambroxol Hydrochloride in commercial pharmaceutical preparation by using simple solvent Distilled water. The results of the tablet analysis were validated with respect to accuracy (recovery), linearity, Limit of Detection and Limit of Quantification and specificity were found to be satisfactory.

Keywords

Ambroxol Hydrochloride, UV Spectrophotometry, Absorbance Maxima, Derivative Spectroscopy.

Full Text